Cefuroxime Axetil (CFA) is one of the most widely prescribed third generation cephalosporin comes in BCS classification as ClassII drug (i.e. High permeability and Low solubility) which has a wide range usage in various diseases. The half life and the bioavailability is poor. These parameters encouraged developing a gastroretentive floating microspheres delivery system for Cefuroxime Axetil. In this study we prepare floating microspheres by emulsion diffusion technique using Eudragit S100 and HPMC with Glycerin Monostereate as wall reinforcing agent and evaluate for compability, morphological and dissolution studies the study also concluded that the microsphere with good entrapping capacity and morphology can be prepared with improving the half life, bioavailability and dissolution rate.
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